Comparison of the potency of a variety of β-glucans to induce cytokine production in human whole blood:

Innate Immunity

IlkaNoss¹ 

关键词: Beta-glucans;    inflammation;    innate immunity;    curdlan;    pustulan;    whole blood stimulation;   

DOI  :  10.1177/1753425912447129

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

β-Glucans are components of fungal cell walls and potent stimulants of innate immunity. The majority of research on biological activities of glucans has focused on β-(1→3)-glucans, which have been implicated in relation to fungal exposure-associated respiratory symptoms and as important stimulatory agents in anti-fungal immune responses. Fungi—and bacteria and plants—produce a wide variety of glucans with vast differences in the proportion and arrangement of their β-(1→3)-, -(1→4)- and -(1→6)-glycosidic linkages. Thus far, the pro-inflammatory potential of different β-glucans has not been studied within the same experimental model. Therefore, we compared the potency of 13 different glucan preparations to induce in vitro production of IL-1β, IL-6, IL-8 and TNF-α in human, whole blood cultures. The strongest inducers of all cytokines were pustulan [β-(1→6)-glucan], lichenan [β-(1→3)-(1→4)-glucan], xyloglucan [β-(1→4)-glucan] and pullulan [α-(1→4)-(1→6)-glucan]. Moderate-to-strong cytokine production was obs...

【 授权许可】

CC BY