Vitamin C supplementation in the critically ill: A systematic review and meta-analysis:

SAGE Open Medicine

MichaelZhang¹ 

关键词: Critical care;    emergency medicine;    respiratory medicine;    sepsis;    nutrition;    respiratory distress;    shock;    vitamin C;    acute respiratory distress syndrome;   

DOI  :  10.1177/2050312118807615

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Low plasma levels of vitamin C are associated with adverse outcomes, including increased mortality, in critically ill patients. Several trials have suggested that the administration of intravenous vitamin C in this setting may have beneficial effects, such as reducing the incidence of organ failure and improving survival. However, these studies have generally involved combination therapies consisting of vitamin C along with other antioxidants, confounding the effects of vitamin C alone. The primary objective of this meta-analysis is to investigate the effects of isolated intravenous supplementation of vitamin C in adults with critical illness.Methods:A database search was conducted for studies on the use of intravenous vitamin C in adult patients with critical illness. The primary outcome assessed was mortality at the longest follow-up time available. Secondary outcomes were the duration of mechanical ventilation, duration of vasopressor support, fluid requirements, and urine output in the firs...

【 授权许可】

CC BY