ПАТОМОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ ПЕЧЕНИ БЕЛЫХ МЫШЕЙ ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ ЧУМНОЙ ИНФЕКЦИИ, ВЫЗВАННОЙ YERSINIA PESTIS С РАЗНЫМ ПЛАЗМИДНЫМ СОСТАВОМ

Acta Biomedica Scientifica

Татьяна Пантелеевна Старовойтова¹  Михаил Юрьевич Котлов¹  Сергей Владимирович Балахонов¹  Геннадий Борисович Мухтургин¹  Светлана Александровна Витязева¹  Валентина Ивановна Дубровина¹ 

[1] ФКУЗ Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока Роспотребнадзора

关键词: печень;    Yersinia pestis;    гепатоциты;    митоз;    гранулёма;    liver;    Yersinia pestis;    hepatocyte;    mitosis;    granuloma;   

DOI  :  10.12737/article_59a614fbe83145.69615594

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Data of histological study of pathomorphological changes in liver of white mice with experimental plague are represented in the article. An important element in evaluation and prediction of the pathological process in the liver is the analysis of hepatocyte karyokinesis, the mitotic index calculation, the counting number of atypical mitosis and the degree of organ regeneration ability. Dynamics of these liver changes at infection process in experimental animals caused by Yersinia pestis plasmid variants was investigated in this work. The variability of liver injuries was shown depending on plasmid-associated virulence of the infection agent. It was proved that the Y. pestis strain carrying three basic pYP (6 mDa), pYV (45 mDa), pYT (61 mDa) plasmids caused the most severe systemic disease with lethal outcome as a rule. Lack of species-specific plasmids and especially virulence and pathogenicity plasmids reduced the rate of infection process generalization and the ability of the pathogen to initiate pathological changes incompatible with the microorganism life. Therefore, all morphological liver changes in experimental plague infection are directly dependent on plasmid profile of the pathogen. The mechanism of toxicity included the damaging effect of the toxin to the cellular structures and failure of the metabolic processes in the organism. Acuity of intoxication and the development of pathological process can be estimated by exploring changes in liver morphology.

【 授权许可】

CC BY