Tau: A Common Denominator and Therapeutic Target for Neurodegenerative Disorders:

Journal of Experimental Neuroscience

AlexanderMaxan¹ 

关键词: Tau;    neurodegenerative disease;    prion;    Huntington disease;    antibody-based therapy;   

DOI  :  10.1177/1179069518772380

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

There is compelling evidence that a number of neurodegenerative diseases share common pathogenic mechanisms. Better understanding these mechanisms will allow us to develop new therapeutic strategies. This commentary follows up on our recent findings that tau pathology can be found in healthy fetal tissue transplanted into the brain of patients with either Huntington or Parkinson disease. We will examine how tau appears to be shared in a number of different conditions and how its expression relates to cognitive decline and disease progression. We will further review pathogenic mechanisms and especially the relevance of the possible prion-like behavior of tau. We will conclude by discussing how all this work opens up novel therapeutic approaches to treating the cognitive impairments related to neurodegenerative diseases using a common strategy.

【 授权许可】

CC BY