Patterns of Circulating Inflammatory Biomarkers in Older Persons with Varying Levels of Physical Performance: A Partial Least Squares-Discriminant Analysis Approach

Frontiers in Medicine

Emanuele Marzetti¹ 

关键词: aging;    gait speed;    inflammaging;    cytokines;    disability;    interleukin;    immune senescence;    multiplex assay;   

DOI  :  10.3389/fmed.2014.00027

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Background: Chronic, low-grade inflammation and declining physical function are hallmarks of the aging process. However, previous attempts to correlate individual inflammatory biomarkers with physical performance in older people have produced mixed results. Given the complexity of the inflammatory response, the simultaneous analysis of an array of inflammatory mediators may provide more insights into the relationship between inflammation and age-related physical function decline. This study was designed to explore the association between a panel of inflammatory markers and physical performance in older adults through a multivariate statistical approach.

【 授权许可】

CC BY