Lifestyle and Dietary Habits Affect Plasma Levels of Specific Cytokines in Healthy Subjects

Frontiers in Nutrition

Mario Sansone¹  Giuseppe Perruolo²  Manuela Lecce²  Maria Rosaria Ambrosio²  Bianca Covelli²  Michele Francesco Di Tolla²  Vittoria D'Esposito²  Pietro Formisano²  Serena Cabaro²  Alessia Parascandolo²  Michele Libutti³  Francesco Cavalli⁴  Saverio Misso⁶ 

[1]Department of Electrical Engineering and Information Technology, Polytechnic and Basic Sciences School, University of Naples Federico II, Naples, Italy

[2]Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

[3]Oncology Department, Azienda Sanitaria Locale Napoli 3 Sud, Naples, Italy

[4]The Anti-inflammaging Company AG, Zurich, Switzerland

[5]URT “Genomic of Diabetes”, Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council (CNR), Naples, Italy

[6]Unit of Transfusion Medicine, Azienda Sanitaria Locale Caserta, Caserta, Italy

关键词: cytokines;    low-grade chronic inflammation;    biomarkers;    body mass index;    inflammaging;   

DOI  :  10.3389/fnut.2022.913176

来源: DOAJ

【 摘 要 】

Low-grade chronic inflammation (LGCI) is a common feature of non-communicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in a healthy population. In total, 150 healthy volunteers were recruited and subjected to questionnaires about the last 7-day lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, and growth factors was analyzed by multiplex ELISA. BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. Aging was characterized by an increase in IL-1b, eotaxin, MCP-1, and MIP-1α. Smoking was related to higher levels of IL-1b and CCL5/RANTES, while physical activity was related to MIP-1α. Within the different eating habits, CRP levels were modulated by eggs, red meat, shelled fruits, and greens consumption; however, these associations were not confirmed in a multivariate model after adjusting for BMI. Nevertheless, red meat consumption was associated with an inflammatory pattern, characterized by an increase in IL-6 and IL-8. IL-8 levels were also increased with the frequent intake of sweets, while a higher intake of shelled fruits correlated with lower levels of IL-6. Moreover, IL-6 and IL-8 formed a cluster that also included IL-1b and TNF-α. In conclusion, age, BMI, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI.

【 授权许可】

Unknown