Cancer Communications | |
Overweight/obese status associates with favorable outcome in patients with metastatic nasopharyngeal carcinoma: a 10-year retrospective study | |
Chen Chen1  Lu-Jun Shen1  Ming Wu1  Yun-Fei Xia1  Xu-Qi Sun1  Tao Chen2  Wang Li2  Ying Zhang3  Pei-Hong Wu3  Wan-Hong Shu3  Chang-Chuan Pan3  | |
[1] Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China;State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China;Zhongshan School of Medical, Sun Yat-sen University, Guangzhou, P. R. China | |
关键词: Nasopharyngeal carcinoma; Body mass index; Metastasis; Prognosis; | |
DOI : 10.1186/s40880-016-0139-6 | |
学科分类:肿瘤学 | |
来源: Springer | |
【 摘 要 】
Although the prognostic impact of body mass index (BMI) in patients with non-metastatic nasopharyngeal carcinoma (NPC) had been extensively studied, its effect among metastatic NPC patients remains unknown. The purpose of this study was to evaluate the prognostic effect of BMI in patients with metastatic NPC. We retrospectively studied 819 patients who were diagnosed with distant metastasis from NPC and received treatment between 1998 and 2007. The patients were divided into three subgroups according to the World Health Organization classifications for Asian populations: underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5–22.9 kg/m2), and overweight/obese (BMI ≥23.0 kg/m2). The associations of BMI with overall survival (OS) and progression-free survival (PFS) were determined by Cox regression analysis. Of the 819 patients, 168 (20.5%) were underweight, 431 (52.6%) were normal weight, and 220 (26.9%) were overweight/obese. Multivariate analysis adjusted for covariates showed that overweight/obese patients had a longer OS than underweight patients [hazard ratio (HR), 0.64; 95% confidence interval (CI), 0.49–0.84] and normal weight patients (HR, 0.72; 95% CI, 0.57–0.90); no significant difference in PFS was observed among these three groups (P = 0.407). Moreover, in stratified analysis, no statistically significant differences in the effect of overweight/obese status among different subgroups were observed. For patients with metastatic NPC, overweight/obese status was associated with longer OS but not longer PFS compared with underweight or normal weight status.
【 授权许可】
CC BY
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