Overweight/obese status associates with favorable outcome in patients with metastatic nasopharyngeal carcinoma: a 10-year retrospective study

Cancer Communications

Chen Chen¹  Lu-Jun Shen¹  Ming Wu¹  Yun-Fei Xia¹  Xu-Qi Sun¹  Tao Chen²  Wang Li²  Ying Zhang³  Pei-Hong Wu³  Wan-Hong Shu³  Chang-Chuan Pan³ 

[1]Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China

[2]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China

[3]Zhongshan School of Medical, Sun Yat-sen University, Guangzhou, P. R. China

关键词: Nasopharyngeal carcinoma;    Body mass index;    Metastasis;    Prognosis;   

DOI  :  10.1186/s40880-016-0139-6

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Although the prognostic impact of body mass index (BMI) in patients with non-metastatic nasopharyngeal carcinoma (NPC) had been extensively studied, its effect among metastatic NPC patients remains unknown. The purpose of this study was to evaluate the prognostic effect of BMI in patients with metastatic NPC. We retrospectively studied 819 patients who were diagnosed with distant metastasis from NPC and received treatment between 1998 and 2007. The patients were divided into three subgroups according to the World Health Organization classifications for Asian populations: underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5–22.9 kg/m2), and overweight/obese (BMI ≥23.0 kg/m2). The associations of BMI with overall survival (OS) and progression-free survival (PFS) were determined by Cox regression analysis. Of the 819 patients, 168 (20.5%) were underweight, 431 (52.6%) were normal weight, and 220 (26.9%) were overweight/obese. Multivariate analysis adjusted for covariates showed that overweight/obese patients had a longer OS than underweight patients [hazard ratio (HR), 0.64; 95% confidence interval (CI), 0.49–0.84] and normal weight patients (HR, 0.72; 95% CI, 0.57–0.90); no significant difference in PFS was observed among these three groups (P = 0.407). Moreover, in stratified analysis, no statistically significant differences in the effect of overweight/obese status among different subgroups were observed. For patients with metastatic NPC, overweight/obese status was associated with longer OS but not longer PFS compared with underweight or normal weight status.

【 授权许可】

CC BY