Human Cancer Immunotherapy with PD-1/PD-L1 Blockade:

Biomarkers in Cancer

PeilinZheng¹ 

关键词: PD-1;    PD-L1;    PD-L2;    blockade;    antitumor immunotherapy;    clinical trials;   

DOI  :  10.4137/BIC.S29325

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

The ligation of programmed cell death-1 (PD-1) to its ligands PD-L1 and PD-L2 counteracts T-cell activation, which is critical in immune tolerance. The persistent high expression of PD-1 and PD-L1 are also observed on tumor-infiltrating lymphocytes and various tumor cells, maintaining the highly suppressive microenvironment in tumor sites and promoting tumor malignancies. The blockade of PD-1 axis with PD-L2 fusion protein or monoclonal antibodies against either PD-1 or PD-L1 has been clinically evaluated in various tumor types. This short review summarizes the progress of PD-1 axis blockade in clinical trials to evaluate its effectiveness in the antitumor immunotherapy.

【 授权许可】

CC BY