ГЕНЕТИЧЕСКАЯ СОСТАВЛЯЮЩАЯ ЧУВСТВИТЕЛЬНОСТИ БОЛЬШОЙ ПЕСЧАНКИ К ВОЗБУДИТЕЛЮ ЧУМЫ

Acta Biomedica Scientifica

Т. В. Мека-Меченко¹  Г. Г. Ковалева¹  В. В. Сутягин²  А. Т. Бердибеков² 

[1] РГП на ПХВ «Казахский научный центр карантинных и зоонозных инфекций им. М. Айкимбаева»;РГУ «Талдыкорганская противочумная станция»

关键词: большая песчанка;    Yersinia pestis;    инфекционная чувствительность;   

DOI  :  10.29413/ABS.2018-3.4.4

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

The susceptibility of the great gerbil to the causative agent of plague is genetically determined. However, there is not enough information  on the involved genes and their effect on this feature in the  literature. Although the sensitivity of gerbils to plague microbe may  depend on many genes, this feature can be described using a  monogenic model of inheritance with one gene. In addition to the  genetic component, other modifying factors of biotic and abiotic  nature may influence the sensitivity of a great gerbil to infection.The aimof the work was to evaluate the role of genetic and modifying factors in the variation of the sensitivity of the great gerbil  to the causative agent of plague. For this, a one-factor  analysis of variance was used. The strength of the effect of the intensity of plague epizootics on sensitivity was calculated by the method of Plokhinsky. As a result, it was found that approximately 87 ± 3.9 % of the total variation of the sensitivity  sign is due to its genetic component and about 13 % to the share of other factors affecting the characteristic (modifying factors). The  conclusion is made that while in studies on the sensitivity of rodents  the effect on regulation of the immune response (specific for specific  antigens) has not been demonstrated, it is necessary to talk about  the general infectious sensitivity of rodents to infections, for  example, the causative agent of plague.

【 授权许可】

CC BY