ГИПОКСИЧЕСКИ-ИШЕМИЧЕСКАЯ ЭНЦЕФАЛОПАТИЯ У НОВОРОЖДЁННЫХ, РОЖДЁННЫХ В ТЯЖЁЛОЙ АСФИКСИИ

Acta Biomedica Scientifica

Наталья Иннокентьевна Михеева¹  Анна Александровна Шишкина²  Евгений Семёнович Филиппов³  Анастасия Сергеевна Ваняркина³  Татьяна Альбертовна Белогорова⁴  Александр Анатольевич Зарубин⁴ 

[1] ОГАУЗ «Иркутский городской перинатальный центр»;ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»;ОГАУЗ «Иркутский городской перинатальный центр»;ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России

关键词: тяжёлая асфиксия в родах;    энцефалопатия;    гипотермия;    новорождённые;    нейропротекция;    severe birth asphyxia;    encephalopathy;    hypothermia;    neonates;    neuroprotection;   

DOI  :  10.12737/article_59a614fd4eb886.85071185

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

This article provides a literature review on the topic of hypoxic-ischemic encephalopathy (HIE). Hypoxic-ischemic brain damage of newborn belongs to one of the most important problems of anesthesiology and resuscitation of newborn babies. Despite progress, perinatal hypoxic-ischemic encephalopathy remains an important cause of child mortality and damage to the central nervous system resulting in a disability of children. HIE clinical signs are nonspecific, so the diagnosis is based on the combination of medical history, physical and neurological examination, laboratory data and neuroimaging techniques. Pathological stage runs when after undergoing asphyxia is the main purpose neuroprotective therapy. The first 6 hours of life of the child, born in asphyxia, is a therapeutic window for the stabilization of the vital functions of the body, during which therapeutic measures are most effective in reducing apoptosis of brain cells. The only method, relatively widely used and effective in infants with severe birth asphyxia, is controlled hypothermia. Published clinical studies show a statistically significant reduction in mortality and severe neuropsychiatric disability at 18 months of life in infants treated with hypothermia. The use of stem cells, the use of hypothermia in combination with xenon or erythropoietin improves neurological outcome: fewer deaths and serious damage to the nervous system. However, these techniques to date are in the experimental stage. Currently, the main task of neonatologists, anesthesiologists and intensive care specialists is not only saving newborn lives, but also creating conditions for proper growth and development of the child.

【 授权许可】

CC BY