Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment:

Innate Immunity

Julien RSDandrieux¹ 

关键词: Canine;    CD163;    chronic enteropathy;    inflammatory bowel disease;    macrophage;   

DOI  :  10.1177/1753425918799865

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) – the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (Mϕ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated Mϕ and CD163 expression as a marker for resident Mϕ in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that Mϕ play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident Mϕ and an increase in early differentiated Mϕ,...

【 授权许可】

CC BY