Expression of epithelial cell-derived cytokine genes in the duodenal andcolonic mucosae of dogs with chronic enteropathy

The Journal of Veterinary Medical Science

Kazuaki SASAKI¹  Misato OGAWA¹  Junsuke SHIRAI¹  Keitaro OHMORI¹  Hiroshi ITOH¹  Hironari OSADA¹  Ayana HASEGAWA¹  Minoru SHIMODA¹  Makoto NAGAI²  Hirotaka KONDO³ 

[1] Cooperative Department of Veterinary Medicine, Facultyof Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho,Fuchu, Tokyo 183-8509, Japan;Department of Bioproduction Science, IshikawaPrefectural University, 1-308 Suematsu, Nonoichi-shi, Ishikawa, 921-8836,Japan;Pathology Service, Synergy Animal General Hospital, 815Ishigami, Kawaguchi, Saitama, 333-0823, Japan

关键词: chronic enteropathy;    dog cytokines;    epithelial cell-derived cytokines;    food-responsive enteropathy;    inflammatory bowel disease;   

DOI  :  10.1292/jvms.16-0451

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

It remains unclear whether epithelial cell-derived cytokines, including interleukin(IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development ofcanine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE),food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the presentstudy, we examined mRNA expression of il-25, il-33 andtslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD.Real-time PCR analysis revealed that mRNA expression of il-33 wassignificantly lower in the duodenum in dogs with FRE than in healthy dogs. The resultssuggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunityin the gut of dogs with CE, and decreased expression of IL-33 may be involved in inductionof FRE. Further studies are required to clarify roles of epithelial cell-derivedcytokines, especially IL-33, in the pathogenesis of canine CE.

【 授权许可】

Unknown