Beyond gene dictation in oral squamous cell carcinoma progression and its therapeutic implications:

Translational Research in Oral Oncology

AjayKumar¹ 

关键词: Carcinogenesis;    DNA methylation;    chromatin;    human papilloma virus;    microRNA;    DNA repair;    inflammation;   

DOI  :  10.1177/2057178X17701463

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

In recent, mechanisms behind transition from normal epithelium to premalignancy and finally to oral carcinoma have been linked to genetic and epigenetic multistep process. These epigenetic changes are heritable, potentially reversible, and presented as epigenetic signature normal and carcinoma cells. Such epigenetic alterations have been suggested as DNA methylation, histone modifications, and small noncoding RNAs. These extragenetic changes have been reported to play a role in the modulation of several key signaling, regulatory, and repair routes in oral squamous cell carcinoma (OSCC) and other carcinomas. In this review, we summarize scientific developments in the last decade, substantiating the role of extra- and beyond genetic molecular signatures in OSCC progression, and potential biomarker and implications in chemotherapy intervention.

【 授权许可】

CC BY