Type 2 diabetes diminishes the benefits of dietary antioxidants: Evidence from the different free radical scavenging potential

卷:186

Cao, Hui ; Xie, Yixi ; Chen, Xiaoqing

关键词: Diabetes;    Plasma proteins;    Antioxidants;    Free radical scavenging;    Polyphenols;   

DOI  :  10.1016/j.foodchem.2014.06.027

学科分类：食品科学和技术

【 摘 要 】

The development of food fortified with polyphenols and polyphenol-rich foods represents a novel approach for preventing or managing type 2 diabetes. Herein, taking advantage of several radical scavenging, the impact of plasma proteins in diabetes on the benefits of dietary polyphenols was investigated. It illustrated that plasma proteins masked the dietary polyphenols, thus reducing their radical scavenging potential. The plasma proteins from type 2 diabetics bind and protect (i.e., mask) the polyphenol antioxidants less effectively than the non-glycosylated ones in healthy blood do. In the blood of diabetics the less-protected (non-masked) antioxidants react with free radicals before being delivered to the tissues that need them. We should pay more attention to in vivo benefits of dietary polyphenols for type 2 diabetics. (C) 2014 Elsevier Ltd. All rights reserved.