Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

卷:115

Black, Lucinda J. ; Burrows, Sally ; Lucas, Robyn M. ; Marshall, Carina E. ; Huang, Rae-Chi ; Ping-Delfos, Wendy Chan She ; Beilin, Lawrence J. ; Holt, Patrick G. ; Hart, Prue H. ; Oddy, Wendy H. ; Mori, Trevor A.

Univ Western Australia

关键词: 25-Hydroxyvitamin D;    Vitamin D;    Cardiometabolic risks;    Adolescents;   

DOI  :  10.1017/S0007114516001185

学科分类：食品科学和技术

【 摘 要 】

Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH) D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH) D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH) D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH) D concentrations were 73.6 (SD 28.2) and 75.4 (SD 25.9) nmol/lat 17 years and 70.0 (SD 24.2) and 74.3 (SD 26.2) nmol/l at 20 years. Deseasonalised serum 25(OH)D-3 concentrations were inversely associated with BMI (coefficient -0.01; 95% CI -0.03, -0.003; P = 0.014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH) D concentrations were inversely associated with log-HOMA-IR (coefficient -0.002; 95% CI -0.003, -0.001; P<0.001) and positively associated with log-TAG in females (coefficient 0.002; 95% CI 0.0008, 0.004; P = 0.003). These associations did not vary over time. There were no significant associations between serum 25(OH) D concentrations and HDL-cholesterol or SBP. Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.