Solar ultraviolet-B radiation and vitamin D: a cross-sectional population-based study using data from the 2007 to 2009 Canadian Health Measures Survey

BMC Public Health

Julia A Knight⁵  Theodore G Shepherd²  Norman A McFarlane²  Reinhold Vieth³  Suneil Malik⁴  Ellie Farahani¹  Philip S Park²  Jamie A Greenfield⁵ 

[1]Centre for EnvironmentUniversity of Toronto, 33 Willcocks Street, Toronto, Canada

[2]Department of Physics, University of Toronto, 60 St. George Street, Toronto, Canada

[3]Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada

[4]Office of Biotechnology, Genomics and Population Health, Public Health Agency of Canada, 180 Queen Street West, Toronto, Canada

[5]Samuel Lunenfeld Research Institute, Mount Sinai Hospital, , 60 Murray street, Box 18, Toronto, Canada

关键词: Public health;    Solar ultraviolet-B irradiance;    25-Hydroxyvitamin D;   

Others  :  1163278
DOI  :  10.1186/1471-2458-12-660

 received in 2012-03-12, accepted in 2012-08-03,  发布年份 2012

【 摘 要 】

Background

Exposure to solar ultraviolet-B (UV-B) radiation is a major source of vitamin D3. Chemistry climate models project decreases in ground-level solar erythemal UV over the current century. It is unclear what impact this will have on vitamin D status at the population level. The purpose of this study was to measure the association between ground-level solar UV-B and serum concentrations of 25-hydroxyvitamin D (25(OH)D) using a secondary analysis of the 2007 to 2009 Canadian Health Measures Survey (CHMS).

Methods

Blood samples collected from individuals aged 12 to 79 years sampled across Canada were analyzed for 25(OH)D (n = 4,398). Solar UV-B irradiance was calculated for the 15 CHMS collection sites using the Tropospheric Ultraviolet and Visible Radiation Model. Multivariable linear regression was used to evaluate the association between 25(OH)D and solar UV-B adjusted for other predictors and to explore effect modification.

Results

Cumulative solar UV-B irradiance averaged over 91 days (91-day UV-B) prior to blood draw correlated significantly with 25(OH)D. Independent of other predictors, a 1 kJ/m² increase in 91-day UV-B was associated with a significant 0.5 nmol/L (95% CI 0.3-0.8) increase in mean 25(OH)D (P = 0.0001). The relationship was stronger among younger individuals and those spending more time outdoors. Based on current projections of decreases in ground-level solar UV-B, we predict less than a 1 nmol/L decrease in mean 25(OH)D for the population.

Conclusions

In Canada, cumulative exposure to ambient solar UV-B has a small but significant association with 25(OH)D concentrations. Public health messages to improve vitamin D status should target safe sun exposure with sunscreen use, and also enhanced dietary and supplemental intake and maintenance of a healthy body weight.

【 授权许可】

   
2012 Greenfield et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Shepherd TG: Dynamics, stratospheric ozone, and climate change. Atmos-Ocean 2008, 46(1):371-392.
• [2]Hegglin MI, Shepherd TG: Large climate-induced changes in UV index and stratosphere-to-troposphere ozone flux. Nat Geosci 2009, 2:687-691.
• [3]Bais AF, Tourpali K, Kazantzidis A, Akiyoshi H, Bekki S, Braesicke P, Chipperfield MP, Dameris M, Eyring V, Garny H, et al.: Projections of UV radiation changes in the 21st century: impact of ozone recovery and cloud effects. Atmos Chem Phys 2001, 11(4):7533-7545.
• [4]Institute of Medicine: Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academics Press; 2011.
• [5]Holick M: Vitamin D: a D-lightful health perspective. Nutr Rev 2008, 66(Suppl 2):182-194.
• [6]MacLaughlin JA, Anderson RR, Holick MF: Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science 1982, 216(4549):1001-1003.
• [7]Hume EM, Sampson LN, Smith HH: On the absorption of vitamin D from the skin. Biochem J 1927, 21(2):362-367.
• [8]Holick MF: Vitamin D deficiency. New Engl J Med 2007, 357:266-281.
• [9]Webb AR: Who, what, where and when – influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol 2006, 92:17-25.
• [10]Engelsen O, Brustad M, Aksnes L, Lund E: Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 2005, 81(6):1287-1290.
• [11]Binkley N, Novotny R, Krueger D, Daida YG, Lensmeyer G, Hollis W, Drezner MK: Low Vitamin D status despite abundant sun exposure. J Clin Endocrinol Metab 2007, 92(6):2130-2135.
• [12]Moy FM: Vitamin D status and its associated factors of free living Malay adults in a tropical country, Malaysia. J Photchem Photobiol B 2011, 104(3):444-448.
• [13]Clemens TL, Henderson SL, Adams JS, Holick MF: Increased skin pigment reduces the capacity of skin to synthesize vitamin D3. Lancet 1982, 1(8263):74-76.
• [14]MacLaughlin JA, Holick MF: Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 1985, 76(4):1536-1538.
• [15]Chen TC, Chimeh F, Lu Z, Mathieu J, Person KS, Zhang A, Kohn N, Martinello S, Berkowitz R, Holick MF: Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys 2007, 460(2):213-217.
• [16]Holick MF: Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 1995, 61(Suppl 3):638-645.
• [17]Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF: Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72(3):690-693.
• [18]Gozdzik A, Barta JL, Wu H, Wagner D, Cole DE, Vieth R, Whiting S, Parra EJ: Low winter time vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area: associations with vitamin D intake and skin pigmentation. BMC Public Health 2008, 8:e336. BioMed Central Full Text
• [19]Rucker D, Allan JA, Fick GH, Hanely DA: Vitamin D insufficiency in a population of healthy western Canadians. CMAJ 2002, 166(12):1517-1524.
• [20]Vieth R, Cole DE, Hawker GA, Trang HM, Rubin LA: Winter time vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it. Eur J Clin Nutr 2001, 55(12):1091-1097.
• [21]Webb AR, Kline L, Holick MF: Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988, 67(2):373-378.
• [22]Fioletov VE, McArthur LJ, Mathews TW, Marrett L: Estimated ultraviolet exposure levels for a sufficient vitamin D status in North America. J Photochem Photobiol B 2010, 100(2):57-66.
• [23]Whiting SJ, Langlois KA, Vatanparast H, Greene-Finestone LS: The vitamin D status of Canadians relative to the 2011 Dietary Reference Intakes: an examination in children and adults with and without supplement use. Am J Clin Nutr 2011, 94(1):128-135.
• [24]Langlois K, Greene-Finestone L, Little J, Hidiroglou N, Whiting S: Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey. Health Reports 2010, 21(2):47-55. Statistics Canada, Catalogue 82–003
• [25]Greene-Finestone LS, Berger C, de Groh M, Hanley DA, Hidiroglou N, Sarafin K, Poliquin S, Krieger J, Richards JB, Goltzman D, et al.: 25-hydroxyvitamin D in Canadian adults: biological, environmental, and behavioural correlates. Osteoporos Int 2011, 22(5):1389-1399.
• [26]Gagnon C, Baillargeon JP, Desmarais G, Fink GD: Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitude. Eur J Endocrinol 2010, 163(5):819-824.
• [27]Baraké R, Weiler H, Payette H, Gray-Donald K: Vitamin D status in healthy free-living elderly men and women living in Quebec, Canada. J Am Coll Nutr 2010, 29(1):25-30.
• [28]Sloka S, Stokes J, Randell E, Newhook LA: Seasonal variation of maternal serum vitamin D in Newfoundland and Labrador. J Obstet Gynaecol Can 2009, 31(4):313-321.
• [29]Giroux S: Canadian Health Measures Survey: sampling strategy overview. Health Reports 2007, 18(Supp):31-36. Statistics Canada, Catalogue 82–003
• [30]Statistics Canada: Canadian Health Measures Survey (CHMS) Data User Guide: Cycle 1. http://www.statcan.gc.ca webcite.
• [31]Day B, Langlois R, Tremblay M, Knoppers B-M: Canadian Health Measures Survey: Ethical, legal and social issues. Health Reports 2007, 18(Suppl):37-51. Statistics Canada, Catalogue 82–003
• [32]Tremblay M, Wolfson M, Gorber SC: Canadian Health Measures Survey: rationale, background and overview. Health Reports 2007, 18(Suppl):7-20. Statistics Canada, Catalogue 82–003
• [33]Bryan S, St-Denis M, Wojtas D: Canadian Health Measures Survey: Clinical operations and logistics. Health Reports 2007, 18(Suppl):53-70. Statistics Canada, Catalogue 82–003
• [34]Madronich S, Flocke S: Theoretical estimation of biologically effective UV radiation at the Earth's surface. In Solar Ultraviolet Radiation Modeling, Measurements and Effects. Edited by Zerefos CS, Bais AF. Berlin: Springer; 1997:I52. ASI Series
• [35]Dee DP, Uppala SM, Simmons AJ, Berrisford P, Poli P, Kobayashi S, Andrae U, Balmaseda MA, Balsamo G, Bauer P, et al.: The ERA-Interim reanalysis: configuration and performance of the data assimilation system. Q J Roy Meteor Soc 2011, 137(656):553-597.
• [36]Cole SR, Chu H, Nie L, Schisterman E: Estimating the odds ratio when exposure has a limit of detection. Int J Epidemiol 2009, 38:1674-1680.
• [37]Millen AE, Wacatawski-Wende J, Pettinger M, Melamed ML, Tylavsky FA, Liu SL, Robbins J, LaCroix AZ, LeBoff MS, Jackson RD: Predictors of serum 25-hydroxyvitamin D concentrations among postmenopausal women: the Women’s Health Initiative Calcium plus Vitamin D Clinical Trial. Am J Clin Nutr 2010, 91(5):1324-1335.
• [38]Chan J, Jaceldo-Siegl K, Fraser GE: Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites. Cancer Causes Control 2010, 21(4):501-511.
• [39]Scragg R, Camargo CA: Frequency of leisure-time physical activity and serum 25-hydroxyvitamin D levels in the US population: results from the Third National Health and Nutrition Examination Survey. Am J Epi 2008, 168(6):577-586.
• [40]Liu E, Meigs JB, Pittas AG, Economos CD, McKeown NM, Booth SL, Jacques PF: Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am J Clin Nutr 2010, 91(6):1622-1633.
• [41]Sahota H, Barnett H, Lesosky M, Raboud J, Vieth R, Knight JA: The association of vitamin D-related information from a telephone interview with 25-hydroxyvitamin D. Cancer Epidemiol Biomarkers Prev 2008, 17(1):232-238.
• [42]Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willet WC: Prospective study of predictor s of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006, 98(7):451-459.
• [43]Gozdzik A, Zhu J, Wong BY, Fu L, Cole DE, Parra EJ: Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry. J Steroid Biochem Mol Biol 2011, 127(3–5):405-412.
• [44]Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, Gallicchio L, Jacobs EJ, Ascherio A, Helzlsouer K, Jacobs KB, et al.: Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 2010, 19(13):2739-2745.