期刊论文详细信息
卷:202 | |
Non-covalent interaction between dietary stilbenoids and human serum albumin: Structure-affinity relationship, and its influence on the stability, free radical scavenging activity and cell uptake of stilbenoids | |
Cao, Hui ; Jia, Xueping ; Shi, Jian ; Xiao, Jianbo ; Chen, Xiaoqing | |
Cent S Univ | |
关键词: Stilbenoids; Structure-affinity relationship; Stability; Free radical scavenging activity; Cell uptake; EA.hy 926 endothelial cells; HUVECs; | |
DOI : 10.1016/j.foodchem.2016.02.003 | |
学科分类:食品科学和技术 | |
【 摘 要 】
Dietary stilbenoids are associated with many benefits for human health, which depend on their bioavailability and bioaccessibility. The stilbenoid-human serum albumin (HSA) interactions are investigated to explore the structure-affinity relationship and influence on the stability, free radical scavenging activity and cell uptake of stilbenoids. The structure-affinity relationship of the stilbenoids-HSA interaction was found as: (1) the methoxylation enhanced the affinity, (2) an additional hydroxyl group increases the affinity and (3) the glycosylation significantly weakened the affinity. HSA obviously masked the free radical scavenging potential of stilbenoids. The stabilities of stilbenoids in different medium were determined as: HSA solution > human plasma > Dulbecco's modified Eagle's medium. It appears that the milk enhanced the cell uptake of stilbenoids with multi-hydroxyl groups and weakened the cell uptake of stilbenoids with methoxyl group on EA.hy 926 endothelial cells. The stilbenoids are hardly absorbed by human umbilical vein endothelial cells in the presence of milk. (C) 2016 Elsevier Ltd. All rights reserved.【 授权许可】
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