Norsesquiterpenoids and triterpenoids from strawberry cv. Falandi

卷:203

Yang, Dan ; Liang, Jian ; Xie, Haihui ; Wei, Xiaoyi

Chinese Acad Sci, Key Lab South China Agr Plant Mol Anal & Genet Im

关键词: Strawberry;    Norsesquiterpenoids;    Triterpenoids;    alpha-Glucosidase inhibitory activity;    Cytotoxicity;   

DOI  :  10.1016/j.foodchem.2016.02.036

学科分类：食品科学和技术

【 摘 要 】

Falandi is a common strawberry (Fragaria x ananassa Duch.) cultivar in southern China. Further study of the chemical constituents in Falandi fruit led to the isolation of nine norsesquiterpenoids and three triterpenoids. Falandioside D (1) and falandins A (2) and B (3) were new norsesquiterpenoids, and the others excluding tormentic acid (11) were found in strawberry for the first time. Compounds 1 and 11 exhibited potent alpha-glucosidase inhibitory activity with the half maximal inhibitory concentration (IC50) values of 565.0 and 27.4 mu M in comparison to acarbose (619.9 mu M). Compounds 3, 7 (blumenol C glucoside), and 11 showed cytotoxicity against human nasopharyngeal carcinoma cell line CNE1 with the IC50 values of 57.6, 56.4, and 36.0 mu M, respectively. Among new compounds, 1 showed 2,2'-azinobis(3-ethylbenzthiazoline- 6-sulfonic acid) (ABTS) radical cation scavenging capacity (IC50 = 36.2 mu M). These results suggested that non-phenolic constituents were also involved in the antidiabetic, antitumour, and antioxidant effects of strawberry fruit. (c) 2016 Elsevier Ltd. All rights reserved.