High Prevalence of Vitamin D Deficiency among Iranian Population: A Systematic Review and Meta-Analysis

Iranian Journal of Medical Sciences

Minoo Mohamadkhani¹  Mahmood Moosazadeh¹  Seyed Taghi Heydari³  Zatollah Asemi⁴  Reza Tabrizi⁵  Mohammad Hossein Dabbaghmanesh⁵  Kamran B Lankarani⁵  Maryam Akbari⁶  Mojtaba Akbari⁷ 

[1] Department of Epidemiology, Faculty of Health, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Epidemiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran;Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

关键词: Vitamin D deficiency;    Meta-analysis;    Iran;   

DOI  :  

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background: The prevention and correction of vitamin D deficiency requires a precise depiction of the current situation and identification of risk factors in each region. The present study attempted to determine these entities using a systematic review and meta-analysis in Iran. Methods: Articles published online in Persian and English between 2000 and November 1, 2016, were reviewed. This was carried out using national databases such as SID, IranMedex, Magiran, and IranDoc and international databases such as PubMed, Google Scholar, and Scopus. The heterogeneity index among the studies was determined using the Cochran (Q) and I2 test. Based on the heterogeneity results, the random-effect model was applied to estimate the prevalence of vitamin D deficiency. In addition, meta-regression analysis was used to determine heterogeneity-suspected factors, and the Egger test was applied to identify publication bias. Results: The meta-analysis of 48 studies identified 18531 individuals with vitamin D deficiency. According to the random-effect model, the prevalence of vitamin D deficiency among male, female, and pregnant women was estimated to be 45.64% (95% CI: 29.63 to 61.65), 61.90% (95% CI: 48.85 to 74.96), and 60.45% (95% CI: 23.73 to 97.16), respectively. The results of the meta-regression analysis indicated that the prevalence of vitamin D deficiency was significantly different in various geographical regions (β=4.4; P=0.023). Conclusion: The results obtained showed a significant prevalence of vitamin D deficiency among the Iranian population, a condition to be addressed by appropriate planning.

【 授权许可】

CC BY