Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs

The Journal of Veterinary Medical Science

Namiko SAITO¹  Masato KAWAGUCHI²  Takehisa SOMA²  Kazumi SASAI² 

[1] Laboratory of Veterinary Internal Medicine, Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Orai-Kita, Izumisano, Osaka 598-8531, Japan;Veterinary Diagnostic Laboratory, Marupi Lifetech Co., Ltd., 103 Fushiocho, Ikeda, Osaka 563-0011, Japan

关键词: antibody;    CSF;    feline coronavirus;    RT-PCR;   

DOI  :  10.1292/jvms.17-0399

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divided into 2 groups; 15 with CSF titer of 180 or lower and 13 with CSF titer of 1640 or higher. In the latter group, reciprocal serum titer/reciprocal CSF titer was 8 or lower, which is extremely lower than normal range (256-2048), and FCoV RNA was detected in all of 11 CSF samples assayed by RT-PCR. Our findings indicate that CSF titer of 1640 or higher may be served as a candidate for the index for diagnosing FIP.

【 授权许可】

Unknown