Genetic characterization of an H2N2 influenza virus isolated from a muskratin Western Siberia

The Journal of Veterinary Medical Science

Mariya SIVAY¹  Ivan SOBOLEV²  Alexander ALEKSEEV²  Marina GULYAEVA³  Alexander SHESTOPALOV³  Lidia SHESTOPALOVA⁴  Yoshihiro SAKODA⁴  Michael SHCHELKANOV⁴  Mizuho SUZUKI⁴  Kirill SHARSHOV⁴ 

[1] Global Station for Zoonosis Control, Global Institutionfor Collaborative Research and Education, Hokkaido University, Sapporo, Hokkaido001-0020, Japan;Laboratory of Microbiology, Department of DiseaseControl, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo,Hokkaido 060-0818, Japan;Novosibirsk State University, Novosibirsk, 630090,Russia;Research Institute of Experimental and ClinicalMedicine, Novosibirsk, 630117, Russia

关键词: H2N2;    influenza virus;    muskrat;    phylogenetic analysis;    Siberia;   

DOI  :  10.1292/jvms.17-0048

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Thirty-two muskrats (Ondatra zibethicus) were captured for surveillanceof avian influenza virus in wild waterfowl and mammals near Lake Chany, Western Siberia,Russia. A/muskrat/Russia/63/2014 (H2N2) was isolated from an apparently healthy muskratusing chicken embryos. Based on phylogenetic analysis, the hemagglutinin and neuraminidasegenes of this isolate were classified into the Eurasian avian-like influenza virus cladeand closely related to low pathogenic avian influenza viruses (LPAIVs) isolated from wildwater birds in Italy and Sweden, respectively. Other internal genes were also closelyrelated to LPAIVs isolated from Eurasian wild water birds. Results suggest thatinterspecies transmission of LPAIVs from wild water birds to semiaquatic mammals occurs,facilitating the spread and evolution of LPAIVs in wetland areas of Western Siberia.

【 授权许可】

Unknown