A Rare Case of Fixed Drug Eruption due to Ondansetron

Iranian Journal of Medical Sciences

Santanu Kumar Tripathi¹  Shashwat Bhattacharyya¹  Aditi Maitra²  Prerna Pathak²  Sabyasachi Paik⁴ 

[1] Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India;Department of Dermatology and Venereology, Calcutta School of Tropical Medicine, Kolkata, India;Department of Ophthalmology, Calcutta National Medical College, Kolkata, India

关键词: Ondansetron;    Hyperpigmentation;    Fixed drug eruption;    5HT3 receptor antagonists;   

DOI  :  

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Abstract Fixed drug eruption (FDE) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. FDE is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. A 27-year-old woman presented with multiple dark patches over her eyelids, mouth, lips, and shoulders of 1 week’s duration. These lesions followed multiple erythematous plaques over the same areas which appeared within 4 hours of the intake of an ondansetron tablet, 12 days previously. The case was diagnosed as post-inflammatory hyperpigmentation following ondansetron-induced FDE. There was an identical episode 1 year earlier due to the intake of the same drug. The causality assessment pointed toward a probable/likely association as per the Naranjo algorithm and the WHO–UMC scale. There have been only a few cases of FDE due to ondansetron in the reported literature.

【 授权许可】

CC BY