Fixed drug eruption to sitagliptin

Journal of Diabetes & Metabolic Disorders

Anish Gupta¹  Mrinal Gupta² 

[1] Acharya Shri Chander College of Medical Sciences, Jammu 180019, India;Sudhaa Skin Centre, Jammu 180019, India

关键词: Oral provocation test;    Fixed drug eruption;    Sitagliptin;   

Others  :  1144155
DOI  :  10.1186/s40200-015-0145-2

 received in 2015-01-18, accepted in 2015-03-07,  发布年份 2015

【 摘 要 】

Fixed drug eruption is a common adverse effect seen with various drugs notably antibiotics, antiepileptics and non-steroidal anti-inflammatory drugs. Herein we report a case of Sitagliptin induced fixed drug eruption in a 46 year old female who developed circumscribed, erythematous macules all over the body within one week of initiation of Sitagliptin. The lesions resolved with residual hyperpigmentation on cessation of the drug. The diagnosis was confirmed by an oral provocation test which led to a reactivation of the lesions. To the best of our knowledge, this is the first case of fixed drug eruption to Sitagliptin reported in the literature.

【 授权许可】

   
2015 Gupta and Gupta; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】

• [1]Desai S, Brinker A, Swann J, Iyasu S: Sitagliptin associated drug allergy: review of spontaneous adverse event reports. Arch Intern Med 2010, 170:1169-71.
• [2]Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al.: A method of estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981, 30:239-45.
• [3]The use of the WHO‑UMC system for standardized case causality assessment [monograph on the Internet]. Uppsala: The Uppsala Monitoring Centre; 2005. Available from: www.who-umc.org/Graphics/24734.pdf.
• [4]Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP: Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia). Dermatol Online J 2012, 18:9.
• [5]Skandalis K, Spirova M, Gaitanis G, Tsartsarakis A, Bassukas ID: Drug-induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase-IV inhibitors plus metformin. J Eur Acad Dermatol Venereol 2012, 26:249-53.
• [6]Nakatani K, Kurose T, Hyo T, Watanabe K, Yabe D, Kawamoto T, et al.: Drug-induced generalized skin eruption in a diabetes mellitus patient receiving a dipeptidyl peptidase-4 inhibitor plus metformin. Diabetes Ther 2012, 3:14.
• [7]Tanaka K, Ogawa Y, Shimada S: Drug eruption caused by sitagliptin, a dipeptidyl peptidase-IV inhibitor. J Dermatol 2012, 39:726-8.
• [8]Shiohara T: Fixed drug eruption: pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 2009, 9:316-21.
• [9]Jung JW, Cho SW, Kim KH, Min KU, Kang HR: Clinical features of fixed drug eruption at a tertiary hospital in Korea. Allergy Asthma Immunol Res 2014, 6:415-20.