Antibacterial and antifungal evaluation of synthesized 9,12-octadecadienoic acid derivatives

Der Pharmacia Lettre

Archana Kapoor¹ 

关键词: Archana Kapoor;    Dina Nath Mishra;    Balasubramanian Narasimhan;    9;    12-octadecadienoic acid;    linoleic acid;    antibacterial activity;    antifungal activity;   

DOI  :  

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

In this study of 9,12-octadecadienoic acid, some aliphatic and aromatic esters were synthesized and screened for antimicrobial activity by following tube dilution method against Gram positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Gram negative bacteria: Escherichia coli, Pseudomonas aeruginosa and two fungal strain: Candida albicans and Aspergillus niger respectively. Compounds L6 (3-Nitrophenyl octadeca-9,12-dienoate) and L7 (4-Nitrophenyl octadeca-9,12-dienoate) were found to be most active compounds against bacterial strains and compound L8 (Benzyl octadeca-9,12-dienoate) emerged as most active antifungal agent among the synthesized derivatives. The structure of all the synthesized compounds was found in agreement with their spectral data.

【 授权许可】

CC BY