Synthesis, characterization, antibacterial, antifungal evaluation of linoleic acid derivatives

Der Pharmacia Lettre

Archana Kapoor¹ 

关键词: Archana Kapoor;    Dina Nath Mishra;    Balasubramanian Narasimhan;    Linoleic acid;    antibacterial activity;    antifungal activity;    minimum inhibitory concentration (MIC);   

DOI  :  

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

In this study, a series of linoleic acid derivatives were synthesized and screened for the invitro antimicrobial activity against a panel of three Gram positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, two Gram negative bacteria: Escherichia coli, Pseudomonas aeruginosa and two fungal strain: Candida albicans and Aspergillus niger respectively. Compound LA09(9Z, 12Z-butyl octadeca-9,12-dienate) was found to be consistently effective against all the strains. The H1NMR and IR spectra were found to be in accord with assigned structures.

【 授权许可】

CC BY