Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals

Endocrine journal

Sakiko Hiraoka¹  Fumio Otsuka¹  Hiroyuki Okada¹  Yuusaku Sugihara¹  Masaya Iwamuro¹  Keita Harada²  Miho Yasuda²  Kou Hasegawa²  Satoshi Fujisawa³  Kanako Ogura-Ochi³ 

[1] Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan;Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan;Endocrine Center, Okayama University Hospital, Okayama 700-8558, Japan

关键词: Acromegaly;    Colonoscopy;    Colorectal cancer;    Colorectal neoplasms;   

DOI  :  10.1507/endocrj.EJ17-0322

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

This study aimed to determine the prevalence of colorectal neoplasms and to investigate the rate of and time required for cecal intubation in patients with acromegaly. A database search performed at our institution identified 29 patients with acromegaly who underwent colonoscopy. Data regarding the endoscopic, biological, and pathological examinations performed were retrospectively reviewed from the clinical records. Subsequently, the rate of and time required for cecal intubation were investigated in 23 patients with acromegaly and compared with the corresponding data of the control group. Control subjects were selected from a 21 matched historical control cohort, according to baseline characteristics. The mean age of the acromegaly group (17 female and 12 male) was 60.4 ± 12.6 years. Twelve patients had adenoma (41.4%), eight patients had hyperplastic polyps (27.6%), three patients had sessile serrated adenoma/polyps (10.3%), and three patients had colon cancer (10.3%). Successful cecal intubation was achieved in all patients in both groups. The difference in the time required for successful intubation between the acromegaly group (15.7 ± 9.8 minutes) and the control group (8.7 ± 6.0 minutes) was statistically significant. Linear regression analysis revealed that increased patient age was significantly related to longer colonoscope insertion times. In conclusion, although cecal intubation during colonoscopy was successful in all participants, it required a longer time in patients with acromegaly. Our results underscore the importance of and certain technical difficulties involved in colonoscopy procedures in patients with acromegaly, especially in older patients.

【 授权许可】

Unknown