Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia andhyperglycemia in the WBN/Kob-Leprfa rat, a new model of type 2diabetes mellitus

The Journal of Veterinary Medical Science

Kaoru WAKABAYASHI¹  Yuki NAKAMURA¹  Fumitoshi ASAI¹  Junichi NAMEKAWA¹  Yoshiichi TAKAGI¹  Mitsuyuki SHIRAI¹  Dai NAGAKUBO¹  Ayaka WATANABE¹ 

[1] Laboratory of Veterinary Pharmacology, School ofVeterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201,Japan

关键词: diet-induced obesity;    fructose-rich diet;    high-fat diet;    type 2 diabetes;    WBN/Kob-Leprfa rat;   

DOI  :  10.1292/jvms.17-0136

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Obesity and type 2 diabetes mellitus (T2DM) are occurring at epidemic-like rates, andthese epidemics appear to have emerged largely from changes in daily diet. In the presentstudy, we compared effects of high-fat diet (HFD) and fructose-rich diet (FRD) inWBN/Kob-Leprfa (WBKDF) rats that spontaneously developobesity, dyslipidemia and T2DM. After a 4-week feeding of each diet, WBKDF-HFD andWBKDF-FRD rats exhibited aggravated obesity and dyslipidemia compared with WBKDF rats fedstandard diet (STD). In contrast, hyperglycemia developed in WBKDF-STD rats wassignificantly inhibited in WBKDF-FRD rats, but not in WBKDF-HFD rats. The present studydemonstrated that the 4-week feeding of HFD and FRD caused diet-induced obesity with adistinct phenotype in the glucose metabolism in WBKDF rats.

【 授权许可】

Unknown