Obesity Rodent Models Applied to Research with Food Products and Natural Compounds

Obesities

Tânia Martins¹  Luís Miguel Antunes¹  Catarina Castro-Ribeiro¹  Eduardo Rosa¹  Paula Alexandra Oliveira¹  Sílvia Lemos¹  Elisabete Nascimento-Gonçalves¹  Tiago Ferreira¹ 

[1] Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal;

关键词: fatness;    overweight;    animal model;    diet-induced obesity;    high-fat diet;    bioactive compounds;   

DOI  :  10.3390/obesities2020015

来源: DOAJ

【 摘 要 】

Obesity is a disease whose incidence has increased over the last few decades. Despite being a multifactorial disease, obesity results essentially from excessive intake of high-calorie foods associated with low physical activity. The demand for a pharmacological therapy using natural compounds as an alternative to synthetic drugs has increased. Natural compounds may have few adverse effects and high economic impact, as most of them can be extracted from underexploited plant species and food by-products. To test the potential anti-obesogenic effects of new natural substances, the use of preclinical animal models of obesity has been an important tool, among which rat and mouse models are the most used. Some animal models are monogenic, such as the db/db mice, ob/ob mice, Zucker fatty rat and Otsuka Long-Evans Tokushima fatty rat. There are also available chemical models using the neurotoxin monosodium glutamate that induces lesions in the ventromedial hypothalamus nucleus, resulting in the development of obesity. However, the most widely used are the obesity models induced by high-fat diets. The aim of this review was to compile detail studies on the anti-obesity effects of natural compounds or their derivatives on rodent models of obesity as well as a critical analysis of the data.

【 授权许可】

Unknown