Dietary L-serine modifies free amino acid composition of maternal milk andlowers the body weight of the offspring in mice

The Journal of Veterinary Medical Science

Vishwajit Sur CHOWDHURY¹  Mitsuhiro FURUSE²  Satsuki NAGAMACHI²  Shinobu YASUO²  Momoko KODAIRA²  Takeshi YAMAGUCHI²  Takuma NISHIGAWA²  Mayumi TAKAKURA²  Hiromi IKEDA² 

[1] Division for Experimental Natural Science, Faculty ofArts and Science, Kyushu University, Fukuoka 812-8581, Japan;Laboratory of Regulation in Metabolism and Behavior,Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan

关键词: free amino acid;    growth;    L-serine;    maternal milk;    mouse;   

DOI  :  10.1292/jvms.17-0577

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The growth of offspring is affected not only by the protein in maternal milk but also bythe free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAAfor the development of the central nervous system and behavioral activity. However, it isnot clear whether L-Ser is transported into the pool of FAAs contained in milk and therebyaffects the growth of offspring. Using mice, the current study investigated the effects ofdietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as wellas on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantlyaffect the maternal, anxiety-like, or cognitive behaviors of either the dam or theoffspring. The FAA composition notably differed between plasma and milk in dams. In milk,dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine andtaurine levels were decreased. The body weight of the offspring was lowered by dietaryL-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were notaltered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasmaL-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion,the present study found that dietary L-Ser transported easily from maternal plasma to milkand that dietary L-Ser treatment could change the FAA composition of milk, but that anenhanced level of L-Ser in milk did not enhance the plasma L-Ser level in theoffspring.

【 授权许可】

Unknown