Organoids from adult liver and pancreas: Stem cell biology and biomedical utility

Developmental biology

Christopher J.Hindley¹ 

关键词: Organoid;    3D cultures;    Pancreas;    Liver;    Niche signals;    Stem cell;   

DOI  :  10.1016/j.ydbio.2016.06.039

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

The liver and pancreas are critical organs maintaining whole body metabolism. Historically, the expansion of adult-derived cells from these organs in vitro has proven challenging and this in turn has hampered studies of liver and pancreas stem cell biology, as well as being a roadblock to disease modelling and cell replacement therapies for pathologies in these organs. Recently, defined culture conditions have been described which allow the in vitro culture and manipulation of adult-derived liver and pancreatic material. Here we review these systems and assess their physiological relevance, as well as their potential utility in biomedicine.

【 授权许可】

CC BY