Endocrine journal | |
Paraganglioma as a risk factor for bone metastasis | |
Mika Tsuiki1  Hironobu Umakoshi1  Tetsuya Tagami1  Maki Yokomoto-Umakoshi1  Tatsuki Ogasawara1  Kaho HamanakaâHiroshima1  Akira Shimatsu1  Mitsuhide Naruse1  Akiyo Tanabe2  | |
[1] Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;Division of Endocrinology, National Center for Global Health and Medicine, Tokyo, Japan | |
关键词: Pheochromocytoma; Paraganglioma; Bone metastasis; Skeletal-related events; | |
DOI : 10.1507/endocrj.EJ17-0368 | |
学科分类:内分泌与代谢学 | |
来源: Japan Endocrine Society | |
【 摘 要 】
Malignant pheochromocytoma (PHEO) and paraganglioma (PGL) (PHEO and PGL PPGL) are frequently associated with bone metastasis. Bone metastasis requires long-term management and may lead to skeletal-related events (SREs) that remarkably reduce patientsâ quality of life (QOL). The aim of this study was to elucidate the risk factors for developing bone metastasis in patients with PPGL. The medical records of 40 consecutive adult patients with malignant PPGL at the National Hospital Organization Kyoto Medical Center between 2006 and 2016 were reviewed. SREs were defined as pathologic fracture, spinal cord compression, and the need for bone irradiation and/or surgery. PHEO (20/40) and PGL (20/40) were each present in 50% of the patients. Bone was the most frequent site of metastasis, detected in 60% (24/40). Bone metastasis was more frequent in patients with PGL (16/20, 80%) than in patients with PHEO (8/20, 40%) (p = 0.02). Half (12/24) of the patients with bone metastasis had at least one SRE. Extra-skeletal invasion of the spine, defined as local infiltration to the surrounding tissue beyond the cortical bone, was more frequently observed in patients with bone metastasis associated with SREs than without them (p = 0.001). Careful follow-up and management are warranted especially in patients with PGL as a risk factor for bone metastasis and with extra-skeletal invasion of the spine as risk factor of SREs.
【 授权许可】
Unknown
【 预 览 】
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