Paraganglioma as a risk factor for bone metastasis

Endocrine journal

Mika Tsuiki¹  Hironobu Umakoshi¹  Tetsuya Tagami¹  Maki Yokomoto-Umakoshi¹  Tatsuki Ogasawara¹  Kaho Hamanaka‑Hiroshima¹  Akira Shimatsu¹  Mitsuhide Naruse¹  Akiyo Tanabe² 

[1] Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;Division of Endocrinology, National Center for Global Health and Medicine, Tokyo, Japan

关键词: Pheochromocytoma;    Paraganglioma;    Bone metastasis;    Skeletal-related events;   

DOI  :  10.1507/endocrj.EJ17-0368

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Malignant pheochromocytoma (PHEO) and paraganglioma (PGL) (PHEO and PGL PPGL) are frequently associated with bone metastasis. Bone metastasis requires long-term management and may lead to skeletal-related events (SREs) that remarkably reduce patients’ quality of life (QOL). The aim of this study was to elucidate the risk factors for developing bone metastasis in patients with PPGL. The medical records of 40 consecutive adult patients with malignant PPGL at the National Hospital Organization Kyoto Medical Center between 2006 and 2016 were reviewed. SREs were defined as pathologic fracture, spinal cord compression, and the need for bone irradiation and/or surgery. PHEO (20/40) and PGL (20/40) were each present in 50% of the patients. Bone was the most frequent site of metastasis, detected in 60% (24/40). Bone metastasis was more frequent in patients with PGL (16/20, 80%) than in patients with PHEO (8/20, 40%) (p = 0.02). Half (12/24) of the patients with bone metastasis had at least one SRE. Extra-skeletal invasion of the spine, defined as local infiltration to the surrounding tissue beyond the cortical bone, was more frequently observed in patients with bone metastasis associated with SREs than without them (p = 0.001). Careful follow-up and management are warranted especially in patients with PGL as a risk factor for bone metastasis and with extra-skeletal invasion of the spine as risk factor of SREs.

【 授权许可】

Unknown