Validation of simple indexes for nonalcoholic fatty liver disease in western China: a retrospective cross-sectional study

Endocrine journal

Zhiye Xu¹  Weichang Chen²  Jinzhou Zhu²  Mingqing He³  Tingxin Li⁴  Yuping Liu⁴  Yong Zhang⁵ 

[1] Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, China;Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China;Department of Geriatrics, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China;Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People’s Hospital, Chengdu 610031, Sichuan, China;School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China

关键词: Nonalcoholic fatty liver disease;    Non-invasive diagnosis;    Fatty liver index;    Hepatic steatosis index;    Lipid accumulation product;   

DOI  :  10.1507/endocrj.EJ17-0466

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Various noninvasive algorithms have been developed for predicting the presence of nonalcoholic fatty liver disease (NAFLD). The evaluation of the indexes’ diagnostic performance has been reported in Europe and Asia over the past decade; however, external validation of them in China is rare. This study was aimed to evaluate various indexes for NAFLD in western China. It was a retrospective cross-sectional study, using data from a large-scale health check-up project at Sichuan provincial hospital. Receiver operating characteristic (ROC) curves of eight indexes, including the fatty liver index (FLI), the hepatic steatosis index, lipid accumulation product and etc., were developed to predict ultrasonographic NAFLD. There were 13,122 subjects in this study (2,692 NAFLD patients and 10,430 non-NAFLD participants). The area under ROC curve of FLI for predicting NAFLD was 0.880 (95% confidence interval, 0.874–0.886), which was significantly higher than other seven indexes. Accuracy, sensitivity and specificity of FLI for NAFLD were good (cut-off value = 30, 0.782, 0.832, 0.770 and cut-off value = 60, 0.838, 0.443, 0.940, respectively). Furthermore, FLI also presented advantages in expenditure and accessibility, compared with other indexes. It supports FLI as an easily accessible index for physicians and a reliable predictor for NAFLD screening in western China.

【 授权许可】

Unknown