Gender, Sex Hormones, and Pulmonary Arterial Hypertension

Advances in Pulmonary Hypertension

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关键词: Cardiology;    Rheumatology;    Pediatrics;    WHO Group 1- Pulmonary Arterial Hypertension;    WHO Group 5- Pulmonary hypertension with unclear multifactorial mechanisms;    symptoms;    Gender;    PH;    Research;    Neonatal;    Idiopathic (Primary pulmonary hypertension);    Genetics;    Associated Diseases;    Connective Tissue Diseases;    Congenital Heart Disease;    Patent Ductus Arteriosus;    pharmacokinetics;    nitric oxide;    Pulmonary vascular resistance;    vasculogenesis;    vascular remodeling;    intermedial hypertrophy;    endothelial proliferation;    endothelial dysfunction;    angiogenesis;    Endothelin;    Endothelial progenitor cells;    Micro Particles;    tricuspid regurgitation;    Contraceptives;    Estrogen;    Androgens;    Testosterone;    Drug development;    clinical trial endpoints;    REVEAL;    Animal Models of PH;    Monocrotaline rat model;    Portopulmonary hypertension;    Classification;    Epidemiology;   

DOI  :  

学科分类：医学（综合）

来源: Pulmonary Hypertension Association

【 摘 要 】

While the mechanistic details behind the female predominance remain unclear, this gender discrepancy may represent an opportunity for advanced biologic understanding and future therapeutic development. This article will briefly discuss the intersection of human, in vitro, and animal studies of PAH, and highlight the conflicting data that others have discussed and elegantly elaborated upon as the “estrogen paradox” in PAH.7-9.

【 授权许可】

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