A 3D polyhedral metal–organic framework as drug carrier for controllable release

Bulletin of The Chemical Society of Ethiopia

关键词: Drug delivery;    Release;    Porous MOF;   

DOI  :  10.4314/bcse.v31i3.9

学科分类：化学（综合）

来源: Chemical Society of Ethiopia

【 摘 要 】

A new fabrication of {[H 3 O][Cu 6 (tpta) 3 (DMA) 4 (COO)]∙12H 2 O∙7DMA} ( 1 ) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the1was around 47.3 wt% per gram of dehydrated1 . Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. Invitrocytotoxicity assays indicated that the1possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.                KEY WORDS : Drug delivery, Release, Porous MOF Bull. Chem. Soc. Ethiop.2017 , 31(3), 457-463. DOI:http://dx.doi.org/10.4314/bcse.v31i3.9.

【 授权许可】

Unknown