Binary and ternary cocrystals of sulfa drug acetazolamide with pyridine carboxamides and cyclic amides

IUCrJ

Bolla, G.¹  Nangia, A.¹ 

[1] School of Chemistry, University of Hyderabad, Prof. C. R. Rao Road, Central University PO, Hyderabad 500 046, India

关键词: CRYSTAL ENGINEERING;    CO-CRYSTALS;    CRYSTAL DESIGN;    HYDROGEN BONDING;    PHARMACEUTICAL SOLIDS;   

DOI  :  10.1107/S2052252516000543

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers. Binary adducts of acetazolamide (ACZ) with lactams (valerolactam and caprolactam, VLM, CPR), cyclic amides (2-pyridone, labeled as 2HP and its derivatives MeHP, OMeHP) and pyridine amides (nicotinamide and picolinamide, NAM, PAM) were obtained by manual grinding, and their single crystals by solution crystallization. The heterosynthons in the binary cocrystals of ACZ with these coformers suggested a ternary combination for ACZ with pyridone and nicotinamide. Novel supramolecular synthons of ACZ with lactams and pyridine carboxamides are reported together with binary and ternary cocrystals for a sulfonamide drug. This crystal engineering study resulted in the first ternary cocrystal of acetazolamide with amide coformers, ACZ–NAM–2HP (1:1:1).

【 授权许可】

CC BY