Quaternary cocrystals: combinatorial synthetic strategies based on long-range synthon Aufbau modules (LSAM)

IUCrJ

Mir, N.A.¹  Dubey, R.¹  Desiraju, G.R.¹ 

[1]Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012, India

关键词: LONG-RANGE SYNTHON AUFBAU MODULE;    CRYSTAL ENGINEERING;    INERMOLECULAR INTERACTIONS;    POLYMORPHISM;    COCRYSTALS;    CRYSTAL DESIGN;   

DOI  :  10.1107/S2052252515023957

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

A synthetic strategy is outlined whereby a binary cocrystal may be developed in turn into a ternary and finally into a quaternary cocrystal. The strategy hinges on the concept of the long-range synthon Aufbau module (LSAM) which is a large supramolecular synthon containing more than one type of intermolecular interaction. Modulation of these interactions may be possible with the use of additional molecular components so that higher level cocrystals are produced. We report six quaternary cocrystals here. All are obtained as nearly exclusive crystallization products when four appropriate solid compounds are taken together in solution for crystallization.

【 授权许可】

CC BY