Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives

Croatica Chemica Acta

Maurić, Maja¹  Starčević, Kristina¹  Mašek, Tomislav²  Racané, Livio³  Roškarić, Petra⁴  Cindrić, Maja⁴  Karminski-Zamola, Grace⁴  Perin, Nataša⁴  Dogan, Jasna⁵ 

[1] Department of Animal Husbandry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia;Department of Animal Nutrition and Dietetics, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia;Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia;Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia;Pliva – TAPI R&D Chemistry, Prilaz baruna Filipovića 29, 10000 Zagreb, Croatia

关键词: amidines;    benzimidazoles;    benzothiazoles;    antioxidative activity in vitro;   

DOI  :  10.5562/cca3146

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

Herein we present the synthesis of versatile amidino substituted benzothiazole 3–10 and benzimidazole 12–19 derivatives substituted with the variable number of hydroxy and methoxy groups. Furthermore, the synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, ABTS and FRAP. The obtained results indicated that the variable number of hydroxy groups together with the type of the amidino substituent strongly influenced the antioxidative activity and reducing power of tested compounds. The most promising antioxidative activity showed trihydroxy substituted compounds 6, 10, 15 and 19. In general, it was noticed that unsubstituted amidino group induced the more pronounced activity in comparison to derivatives bearing 2-imidazolinyl group.

【 授权许可】

CC BY