The British Journal of Nutrition | |
PUFA status at birth and allergy-related phenotypes in childhood: a pooled analysis of the Maastricht Essential Fatty Acid Birth (MEFAB) and RHEA birth cohorts | |
Nikos Stratakis1  Manolis Kogevinas2  Marij Gielen3  Katerina Margetaki4  Renate H. M. de Groot5  Maria Apostolaki6  Georgia Chalkiadaki7  Marina Vafeiadi8  Vasiliki Leventakou9  Roger W. Godschalk1,10  | |
[1] 1Section of Complex Genetics and Epidemiology, Department of Genetics and Cell Biology, School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands;10School CAPHRI: Care and Public Health Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands;2Department of Social Medicine, Faculty of Medicine, University of Crete, 71 003 Heraklion, Greece;3Welten Institute – Research Centre for Learning, Teaching and Technology, Open University of the Netherlands, 6419 AT Heerlen, The Netherlands;4Environmental Chemical Processes Laboratory (ECPL), Department of Chemistry, University of Crete, 71 003 Heraklion, Greece;5Department of Pharmacology & Toxicology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands;6ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), 08003 Barcelona, Spain;7IMIM Hospital del Mar Medicine Research Institute, 08003 Barcelona, Spain;8Spanish Consortium for Research in epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain;9The Cyprus Institute, 2121 Nicosia, Cyprus | |
关键词: PUFA; Cord blood; Asthma; Eczema; Rhinitis; Childhood; | |
DOI : 10.1017/S0007114517003348 | |
学科分类:卫生学 | |
来源: Cambridge University Press | |
【 摘 要 】
Lower prenatal exposure to n-3 PUFA relative to n-6 PUFA has been hypothesised to influence allergy development, but evidence remains largely inconsistent. In the Dutch Maastricht Essential Fatty Acid Birth (MEFAB) (n 293) and Greek RHEA Mother–Child (n 213) cohorts, we investigated whether cord blood phospholipid PUFA concentrations are associated with symptoms of wheeze, asthma, rhinitis and eczema at the age of 6–7 years. Information on allergy-related phenotypes was collected using validated questionnaires. We estimated relative risks (RR) and 95 % CI for associations of PUFA with child outcomes using multivariable generalised linear regression models. In pooled analyses, higher concentration of the n-3 long-chain EPA and DHA and a higher total n-3:n-6 PUFA ratio were associated with lower risk of current wheeze (RR 0·61; 95 % CI 0·45, 0·82 per sd increase in EPA+DHA and 0·54; 95 % CI 0·39, 0·75 per unit increase in the n-3:n-6 ratio) and reduced asthma risk (RR 0·50; 95 % CI 0·31, 0·79 for EPA+DHA and 0·43; 95 % CI 0·26, 0·70 for the n-3:n-6 ratio). No associations were observed for other allergy-related phenotypes. The results were similar across cohorts. In conclusion, higher EPA and DHA concentrations and a higher n-3:n-6 fatty acid ratio at birth were associated with lower risk of child wheeze and asthma. Our findings suggest that dietary interventions resulting in a marked increase in the n-3:n-6 PUFA ratio, and mainly in n-3 long-chain PUFA intake in late gestation, may reduce the risk of asthma symptoms in mid-childhood.
【 授权许可】
CC BY
【 预 览 】
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