Higher cord blood 25-hydroxyvitamin D concentrations reduce the risk of early childhood eczema: in children with a family history of allergic disease

World Allergy Organization Journal

Maria Makrides³  Lisa G. Smithers¹  Clark M. Skeaff⁴  Thomas R. Sullivan¹  Debra Jane Palmer² 

[1] School of Population Health, University of Adelaide, Adelaide 5005, SA, Australia;School of Paediatrics and Child Health, University of Western Australia, Subiaco 6008, WA, Australia;School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide 5005, SA, Australia;Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand

关键词: Vitamin D;    Pregnancy;    Eczema;    Cord blood;    Allergy prevention;   

Others  :  1234610
DOI  :  10.1186/s40413-015-0077-9

 received in 2015-05-12, accepted in 2015-07-30,  发布年份 2015

【 摘 要 】

Background

In recent years the role of vitamin D status in early life on the development of allergic disease has generated much interest. The aim of this study was to determine whether cord blood vitamin D concentrations were associated with risk of early childhood allergic disease.

Methods

Measurements of cord blood 25-hydroxyvitamin D [25(OH)D] concentrations were available in 270 mother-child pairs who were participating in the allergy follow-up (n = 706) of the Docosahexaenoic Acid to Optimise Mother Infant Outcome randomised controlled trial. All of the children had a hereditary risk of allergic disease. The diagnosis of allergic disease was made during medical assessments at 1 and 3 years of age.

Results

The mean (standard deviation) standardised cord blood 25(OH)D concentration was 57.0 (24.1) nmol/L. The cumulative incidence of eczema to 3 years of age, n = 101/250 (40 %) was associated with standardised cord blood 25(OH)D concentration, with a 10 nmol/L rise in 25(OH)D concentration reducing the risk of eczema by 8 % (relative risk 0.92, 95 % confidence interval 0.86–0.97; P = 0.005). This association was stronger at 1 year of age, when a 10 nmol/L rise in standardised cord blood 25(OH)D concentration reduced the risk of eczema by 12 % (relative risk 0.88, 95 % confidence interval 0.81–0.96; P = 0.002). No associations between cord blood 25(OH)D concentrations and development of allergic sensitisation, allergic rhinitis or asthma in early childhood were found.

Conclusion

In children with a family history of allergic disease, a higher cord blood 25(OH)D concentration appears to be associated with reduced risk of eczema in early childhood.

Trial registration

Australian New Zealand Clinical Trials Registry ACTRN12610000735055 (DOMInO trial: ACTRN12605000569606).

【 授权许可】

   
2015 Palmer et al.

【 图 表 】

Fig. 1.

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