IgA Nephropathy

Clinical journal of the American Society of Nephrology: CJASN

Jennifer C. Rodrigues² 

[1] and..*Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, Toronto, Ontario, Canada;*Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, Toronto, Ontario, Canada;†Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California

关键词: glomerulonephritis;    IgA nephropathy;    kidney;    immunosuppression;    review;    corticosteroids;    pathology;    crescents;    glomerulonephritis;    IGA;    humans;    immunotherapy;    renal insufficiency;    renal insufficiency;    chronic;    translational medical research;   

DOI  :  10.2215/CJN.07420716

学科分类：泌尿医学

来源: American Society of Nephrology

【 摘 要 】

IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of clinical trials that have provided important insights regarding immunotherapy in IgAN. In this article, we review emerging developments in clinical and translational IgAN research and describe how these novel findings will influence future strategies to improve the outcome of patients with IgAN.

【 授权许可】

CC BY