Update on Lupus Nephritis

Clinical journal of the American Society of Nephrology: CJASN

Salem Almaani¹ 

[1]Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio..Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio..Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio..

关键词: systemic lupus erythematosus;    Epidemiology and outcomes;    glomerular disease;    glomerulonephritis;    immunosuppression;    nephritis;    humans;    kidney;    kidney failure;    chronic;    Lupus Erythematosus;    Discoid;    Lupus Erythematosus;    Systemic;    lupus nephritis;    Renal Insufficiency;    Chronic;    risk factors;   

DOI  :  10.2215/CJN.05780616

学科分类：泌尿医学

来源: American Society of Nephrology

【 摘 要 】

SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus.

【 授权许可】

CC BY