Pseudomonas Aeruginosa Resistance Phenotypes and Phenotypic Highlighting Methods

Current Health Sciences Journal

Maria Bloiu ; A.T. Bloiu ; Rodica Mnescu ; Carmen Avramescu ; Oana Ionete

关键词: ESBLs;    AmpC;    Carbapenemase;    genotypic resistance;    phenotypic resistance;   

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Pseudomonas aeruginosa genus bacteria are well known for their increased drug resistance (phenotypic ang genotypic resistance). The most important resistance mechanisms are: enzyme production, reduction of pore expression, reduction of the external membrane proteins expression, efflux systems, topoisomerase mutations. These mechanisms often accumulate and lead to multidrug ressitance strains emergence. The most frequent acquired resistance mechanisms are betalactamase-type enzyme production (ESBLs, AmpC, carbapenemases), which determine variable phenotypes of betalactamines resistance, phenotypes which are associated with aminoglycosides and quinolones resistance. The nonenzymatic drug resistance mechanisms are caused by efflux systems, pore reduction and penicillin-binding proteins (PBP) modification, which are often associated to other resistance mechanisms. Phenotypic methods used for testing these mechanisms are based on highlighting these phenotypes using Kirby Bauer antibiogram, clinical breakpoints, and ut off?values recommended by EUCAST 2013 standard, version 3.1.

【 授权许可】

Unknown