Assignments of 1H and 13C NMR signals of Euphorbia factor L1 and investigation of its anticancer activity in vitro

Dynamic Chiropractic

Jian-ye Zhang¹  Hu-biao Chen²  Yi-wen Tao³  Chao Zhang⁴  Li-wu Fu⁴  Xiao-qiong Zheng⁴ 

[1] Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, People'School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People'State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, People's Republic of China.

关键词: CaperEuphorbiaseed;    NMR signals;    anticancer activity.;   

DOI  :  10.5897/JMPR09.473

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

In this article, we reported the isolation and characterization ofEuphorbiafactor L1 from CaperEuphorbiaseed. The complete1H and13C NMR signals were assigned with the help of 1D, 2D NMR techniques. In addition, the anticancer activities ofEuphorbiafactor L1 were investigated. It exhibited potent cytotoxicity to KB, KBv200, MCF-7 and MCF-7/ADR cells with the IC50values of 30.83 ± 2.93, 28.11 ± 3.08, 39.47 ± 4.03 and 42.69 ± 4.27 μg/ml, respectively.

【 授权许可】

Unknown