Synthesis, docking and anticancer activity studies of D-proline-incorporated wainunuamide

Journal of Chemical Sciences

Sunil V Mali¹  M Himaja1²  A Ranjitha1² 

[1] Medicinal Chemistry Division, Piramal Life Science Ltd., Mumbai 400 060, India$$;School of Advanced Sciences, Pharmaceutical Chemistry Division, VIT University, Vellore 632 014, India$$

关键词: Cyclic octapeptide;    molecular docking;    solution phase synthesis;    anticancer activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

D-proline-incorporated wainunuamide — a cyclic octapeptide was synthesized and characterized by FTIR, 1H and 13C NMR and Mass spectral analysis. Molecular docking studies were carried out for the designed cyclic octapeptide and the results showed greater affinity for HPV18-2IOI receptor (HeLa cancer cell line). The synthesized cyclic octapeptide exhibited potent anticancer activity against HeLa cancer cells.

【 授权许可】

Unknown