Crude extracts and semi-fractions from Myracrodruon urundeuva with antibacterial activity against American type culture collection (ATCC) strains of clinical relevance

Dynamic Chiropractic

Carvalho Michelle da Silva¹  Ferreira Barbara Caroline Mota² 

[1] Bioprospecting and Genetic Resources Laboratory, State University of Montes Claros, Brazil.;Environmental Microbiology Laboratory, State University of Montes Claros, Brazil.

关键词: Myracrodruon urundeuva(Fr. All.);    antibacterial activity;    extracts;    extract.;   

DOI  :  10.5897/JMPR12.1264

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

The objective of this study was to investigate the antibacterial activity of crude and semi-pure extracts obtained fromMyracrodruon urundeuva(Aroeira do sertão) against clinically important ATCC bacterial strains by preparative thin layer chromatography (TLC). The results indicate potential activity as assessed by minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) analysis. The crude and semi-pure extracts, obtained from the leaves and bark ofM. urundeuva(Fr. All.), have a broad antibacterial spectrum and are capable of inhibiting the growth of different Gram-positive and Gram-negative bacterial strains. The phytochemical analysis of the leaves revealed the presence of hydrolysable tannins, flavonoids, saponins, terpenes and steroids. However, extracts from the Aroeira tree leaves showed larger inhibition zones for the species of Gram-positive bacteria than for Gram-negative species. It is possible that the active compounds present in these extracts act by inhibiting the synthesis of peptidoglycan in the cell wall, particularly in Gram-positive bacteria. The proven antibiotic action of crude and semi-pure extract from Aroeira leaves can be explored to facilitate their application as pharmaceutical adjuvants in antibiotic preparations.

【 授权许可】

Unknown