Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

Frontiers in Cellular and Infection Microbiology

Mirazimi, Ali¹  Tsergouli, Katerina²  Tsioka, Katerina²  Papa, Anna² 

[1] Department of Clinical Microbiology, Institute for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden;Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

关键词: Crimean-Congo hemorrhagic fever virus;    tick;    Humans;    interactions;    immune resonse;   

DOI  :  10.3389/fcimb.2017.00213

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment required for CCHFV studies. Among ticks, Hyalomma spp. are considered the most competent virus vectors. CCHFV evades the tick immune response, and following its replication in the lining of the tick’s midgut, it is disseminated by the hemolymph in the salivary glands and reproductive organs. The introduction of salivary gland secretions into the host cells is the major route via which CCHFV enters the host. Following an initial amplification at the site of inoculation, the virus is spread to the target organs. Apoptosis is induced via both intrinsic and extrinsic pathways. Genetic factors and immune status of the host may affect the release of cytokines which play a major role in disease progression and outcome. It is expected that the use of new technology of metabolomics, transcriptomics and proteomics will lead to improved understanding of CCHFV-host interactions and identify potential targets for blocking the CCHFV transmission.

【 授权许可】

CC BY