IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis

Frontiers in Cellular and Infection Microbiology

Alvar, Jorge¹  Ghosh, Prakash²  Chowdhury, Rajashree²  Hossain, Faria²  Mondal, Dinesh²  Ibarra-Meneses, Ana V.³  Moreno, Javier³  Carrillo, Eugenia³ 

[1] Drugs for Neglected Diseases Initiative, Geneva, Switzerland;Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh;WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, Instituto de Salud Carlos, Madrid, Spain

关键词: chemokine;    cytokine;    biomarker;    Leishmaniasis;    Whole blood assay;    asymptomatic;    Treatment;   

DOI  :  10.3389/fcimb.2017.00200

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

New biomarkers are needed for monitoring the effectiveness of treatment for visceral leishmaniasis (VL). They might also improve the detection of the asymptomatic population in Leishmania-endemic areas. This paper examines the IL-2, IFN-g, IFN-g-induced protein 10 (IP-10) and monokine-induced-by-IFN-g (MIG) levels in whole blood - stimulated in vitro with soluble Leishmania antigen (SLA) - taken from asymptomatic individuals and patients treated for VL living in a post-outbreak (L. infantum) area in Spain, and in an endemic (L. donovani) area of Bangladesh. IP-10 was found to be an accurate global marker of asymptomatic subjects with positive cellular/humoral tests, while MIG was found to be a better marker of contact with L. donovani than IL-2 but no for those with L.infantum. Determining IP-10, MIG and IFN-g levels proved useful in monitoring the cellular immune response following treatment for active disease caused by L. infantum.

【 授权许可】

CC BY