Interactions of Intestinal Bacteria with Components of the Intestinal Mucus

Frontiers in Cellular and Infection Microbiology

lix²  Harel, José³  Sicard, Jean-Fé⁴  e⁶  Le Bihan, Guillaume⁷  Jacques, Mario⁸  Vogeleer, Philippe⁹ 

[1]Optimale (Op+Lait), Faculté

[2]de Mé

[3]de Montré

[4]Centre de Recherche en Infectiologie Porcine et Aviaire, Faculté

[5]Regroupement de Recherche Pour un Lait de Qualité

[6]al, Saint-Hyacinthe, QC, Canada

[7]decine Vé

[8]rinaire, Université

[9]té

关键词: Mucus;    Commensals.;    pathogens;    Biofilm;    microbiota;    microflora;    Goblet Cells;   

DOI  :  10.3389/fcimb.2017.00387

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

The human gut is colonized by a variety of large amounts of microbes that are collectively called intestinal microbiota. Most of these microbial residents will grow within the mucus layer that overlies the gut epithelium and will act as the first line of defense against both commensal and invading microbes. This mucus is essentially formed by mucins, a family of highly glycosylated protein that are secreted by specialize cells in the gut. In this Review, we examine how commensal members of the microbiota and pathogenic bacteria use mucus to their advantage to promote their growth, develop biofilms and colonize the intestine. We also discuss how mucus-derived components act as nutrient and chemical cues for adaptation and pathogenesis of bacteria and how bacteria can influence the composition of the mucus layer.

【 授权许可】

CC BY