Evaluation of anti-inflammatory effect of Zosima absinthifolia and deltoin

Dynamic Chiropractic

in Saltan Ccedil¹  Ouml²  zlem Bahadir³  lccedil⁴  Guuml⁵ 

[1]Yıl University, Faculty of Medicine, Department of Pharmacology, 65300 Van, Turkey.

[2]Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Turkey.

[3]Yü

[4]ncü

[5]zü

关键词: Anti-inflammatory activity;    deltoin;    umbelliferae;    Zosima.;   

DOI  :  10.5897/JMPR10.106

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

In this study, n-Hexane extracts prepared from aerial part ofZosima absinthifolia(ZAA) and the root ofZ. absinthifolia(ZAR) (Umbelliferae) as well as deltoin were evaluated for their anti-inflammatory activity using the carrageenan-induced rat paw oedema test. The anti-inflammatory activity ofZ. absinthifoliawas not found to be significantly different at doses of 25 and 50 mg/kg. However, the aerial part of ZAA at 75 mg/kg, i.p., and Deltoin at 10 mg/kg, i.p. showed a significant reduction with 86.56 and 71.05% respectively in rat paw oedema induced by carrageenan against the reference anti-inflammatory drug indomethacin (3 mg/kg, i.p.) (87%). The ED50of deltoin, ZAA and ZAR were determined as 5.08, 69.82 and 38.51 mg/kg, respectively. Furthermore, content of deltoin and columbianadin in both ZAA and ZAR were also analyzed by HPLC. Deltoin content of plant was found higher than the columbianadin content in ZAA and ZAR. The present study reveals that the aerial part ofZ. absinthifoliapossesses promising anti-inflammatory activity in rats.

【 授权许可】

Unknown