Incidence of AQP4-IgG seropositive neuromyelitis optica spectrum disorders in the Netherlands: About one in a million:

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Dörte Hamann¹  E Daniëlle van Pelt²  Immy A Ketelslegers²  Yu Yi M Wong²  Dorine AM Siepman²  Rogier Q Hintzen² 

[1] Department of Immunopathology and Blood Coagulation, Sanquin Diagnostic Services, the Netherlands;Department of Neurology, MS Centre Erasmus, the Netherlands

关键词: Epidemiology;    Devic’s syndrome;    neuromyelitis optica spectrum disorders;    AQP4-IgG;   

DOI  :  10.1177/2055217315625652

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Neuromyelitis optica (NMO) is a rare autoimmune disease affecting the optic nerves and spinal cord. In the majority of NMO patients anti-aquaporin-4 antibodies (AQP4-IgG) are detected. Here we assessed a nationwide incidence of AQP4-IgG-seropositive NMO spectrum disorders (NMOSD) in the Netherlands based on results of one central laboratory. Data were collected since the introduction of the highly sensitive cell-based assay for six consecutive years. Samples from 2795 individual patients have been received; of them 94 (3.4%) were seropositive. Based on the Dutch population with 16.6 million inhabitants, the mean incidence of AQP4-IgG-seropositive NMOSD was calculated at 0.09 per 100,000 people.

【 授权许可】

CC BY-NC